چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | طاهره قدیری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 71787 |
| عنوان فارسی مقاله | آسیب و مرگ نورونی به دنبال ضربه مغری به دلیل تحریک بیش از حد |
| عنوان لاتین مقاله | Neuronal injury and death following focal mild brain injury due to network excitability |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | کنگره بین المللی علوم اعصاب پایه و بالینی هشتم |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/09/27 الی 1398/09/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.civilica.com/Paper-NSCMED08-NSCMED08_193=Neuronal-injury-and-death-following-focal-mild-brain-injury-due-to-network- |
| آدرس علمی (Affiliation) نویسنده متقاضی | دانشگاه علوم پزشکی تبریز دانشکده علوم نوین، دپارتمان علوم اعصاب |
| نویسنده | نفر چندم مقاله |
|---|---|
| طاهره قدیری | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the histopathological and molecular modifications induced by seizures on traumatized brain. Materials and Methods: Using a new method, head was traumatized and seizures were evoked by sub-convulsive dose of pentylenetetrazole (PTZ) fifteen days after induction of focal mild TBI. Convulsion assessments were performed one hour after PTZ injection and was followed by histopathological and molecular evaluations. Results: A significantly higher score and longer duration of seizure attacks as well as higher number of epileptiform discharges were observed in the TBI+PTZ group compared to sham and TBI groups. An elevated number of apoptotic cells was observed in the TBI+PTZ group compared to sham and TBI rats. Molecular investigations revealed higher levels of Bax/Bcl2 ratio, Caspase 3, and NF-κB in the TBI+PTZ group compared to the other animal groups. The value of Nrf2 did not change after mild TBI compared to sham and PTZ control groups. Occurrence of seizures after TBI, however, significantly decreased the level of Nrf2. Conclusion: Our data indicated that seizure occurrence following mild TBI aggravates cell injury and death via activation of neuroinflammatory processes and may increase the risk of PTE. Additionally, our results suggest a potential protective role of Nrf2 after chemically evoked PTE. |
| کلمات کلیدی | Apoptosis Convulsive Hippocampus Neuroinflammation Post-traumatic Seizure |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Neuronal injury and death following focal mild brain injury.docx | 1399/03/17 | 22598 | دانلود |
| IMG_4820 (1).jpg | 1399/03/17 | 64125 | دانلود |
