| Recently, the use of nanofibers (NFs) for tissue engineering has been more developed. For this
purpose, we fabricated the NFs (Zein/polycaprolactone/Collagen) (Zein/PCL/Collagen)
incorporated by zinc oxide NPs (ZnO NPs) and Aloe-vera (NFs/ZnO/Alv) using the
electrospinning method. Prepared NFs were studied for their morphological, mechanical, thermal
stability, and hydrophilic properties. Among the developed NFs, those loaded by ZnO (1 wt %)
and Alv (8 wt %) and with Zein/PCL (70:30) displayed the suitable thermal stability and
mechanical properties. The water contact angle of NFs improved by decreasing the Zein/PCL
blending ratio. Cell culture results showed that the NFs had good cytocompatibility. The cell
adhesion potential of this mats were certified with studying by fibroblast cells for various time
intervals (24 h and 72 h). The NFs/ZnO/Alv sample revealed inhibition activity against S. aureus
(19.23 ± 1.35 mm) and E. coli (15.38 ± 1.12 mm) bacteria. Thus, these results offered that the
prepared NFs can be promised as an active scaffold for wound healing uses. |