چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure oftherapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among theseveral cell populations in the tumor microenvironment, macrophages, as one of the most abundant innateimmune cells within the tumor milieu, have attracted extensive attention among several researchers because oftheir critical role in innate pathophysiology of multiple disorders, as well as ovarian cancer. High plasticity andconsequent high ability to adapt to environmental alternations by adjusting their cellular metabolism and im-munological phenotype is the notable characteristic of macrophages. Therefore, the critical function of tumor-associated macrophages in ovarian cancer is highlighted in the growing body of recent studies. In this article, wewill comprehensively focus on significant impacts of the macrophages on ovarian cancer progression, by dis-cussing the role of macrophages as one of the fundamental immune cells present in tumor milieu, in metabolicreprogramming of transformed cells, and involvement of these cells in the ovarian cancer initiation, progression,invasion, and angiogenesis. Moreover, we will summarise recent studies evaluating the effects of targetingmacrophages in ovarian cancer |
| نویسنده | نفر چندم مقاله |
|---|---|
| یوسف یوسف زاده | اول |
| شاهین حلاج | دوم |
| مهدی باغی مورنانی | سوم |
| فرهاد جدیدی نیارق | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tumor associated macrophages in the molecular pathogenesis of ovarian cancer.pdf | 1399/01/29 | 1806206 | دانلود |
