چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction: To evaluate the effect of a herbal mixture (i.e., Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, and Citrus sinensis) alone and in combination with clomiphene citrate (CC) compared to CC on the treatment of polycystic ovary syndrome (PCOS). Material and methods: This single-blind randomized clinical trial was conducted on 60 infertile participants with PCOS who were randomly divided into three groups. After spontaneous or progestin-induced withdrawal bleeding, group 1 (n = 20) received routine treatment with CC (50–150 mg) for three menstrual cycles from the 3rd to 5th day of menstruation for 5 days while group 2 (n = 20) and group 3 (n = 20) received herbal mixture capsules 700 mg/day and the herbal mixture along with CC for 3 months, respectively. Finally, several related parameters were measured, including the level of sex steroids, homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile (primary outcomes), thyroid hormones, and clinical features. The analysis was based on intention-to-treat analysis. Results: No statistically significant differences were observed between the groups in terms of socio-demographic characteristics. However, after adjustment for baseline, luteinizing hormone (aMD = 4.9; 95% CI: 3.7–6.2), luteinizing hormone/follicle-stimulating hormone (aMD = 0.9; 95% CI: 0.7–1.2), total testosterone (aMD = –0.12; 95% CI: –0.2 to –0.01) in group 2 and free testosterone (aMD = –6.0; 95% CI: –9.7 to –2.3) in group 3 revealed a significant difference compared to group 1. In addition, HOMA-IR in group 2 (aMD = –1.3; 95% CI: –2.4 to –0.2) decreased significantly compared to group 1. Further, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol decreased significantly in group 2 (aMD = –21.8; 95% CI: –31.5 to –12.1; aMD = –29.9; 95% CI: –47.9 to –12.0; aMD = –21.2; 95% CI: –31.3 to –11.1; aMD = –5.1; 95% CI: –7.5 to –2.7) and group 3 (aMD = –18.3; 95% CI: –27.4 to –9.2; aMD = –26.9; 95% CI: –43.8 to –9.9; aMD = –21.4; 95% CI: –31.1 to –11.7; aMD = –5.9; 95% CI: –8.3 to –3.6) compared to group 1, respectively. However, high-density lipoproteins cholesterol in group 2 (aMD = 6.8; 95% CI: 2.9–10.7) and group 3 (aMD = 10.7; 95% CI: 7.2–14.7) increased remarkably compared to group 1. Overall, clinical outcomes improved significantly in all groups (p < 0.05). Conclusions: In general, the herbal mixture along with CC was found to improve free testosterone, HOMA-IR, lipid profile, and clinical features of PCOS women. |
| نویسنده | نفر چندم مقاله |
|---|---|
| آرش خاکی | دوم |
| الهه اولاد صاحب مدارک | سوم |
| لعیا فرزدی | پنجم |
| عزیزه فرشباف خلیلی | ششم |
| سولماز اثناعشری | هفتم |
| امیر افشین خاکی | نهم |
| مجید شکوهی برابادی | دهم |
| نوا آینه چی | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The effect of clomiphene.pdf | 1399/10/03 | 142167 | دانلود |
