چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: MicroRNAs (miRNAs) are a large group of small non-coding RNAs with critical functions in the regulation of important genes involved in cellular proliferation and apoptosis, at post-transcription level. Phosphatase and tensin homolog (PTEN) is a best example of miRNAs target genes. In the present study, we aimed to evaluate the expression levels of miR-214 and PTEN in tumor tissues and adjacent normal tissues in patients with breast cancer. Methods: The expression levels of miR-214 and PTEN were measured in tumor tissue and compared to adjacent normal cells in 42 patients with breast cancer by qRT-PCR. Statistical analysis was processed using SPSS 21.0, GraphPad 7.00 software or the Student's t-test. All data from at least three separate experiments are presented. Results: We found a significant downregulation of miR-214 expression levels in tumor tissues in comparison to normal tissues (0.85 ± 0.45 vs. 9.59 ± 1.71; P < .001). In addition, the expression levels of PTEN was also significantly lower in tumor tissues, as compared to adjacent normal tissues (0.75 ± 0.44 vs. 22.72 ± 6.76; P < .001). There was also a significant correlation between miR-214 and PTEN expression and clinicopathological factors including age, tumor size, and cancer grade (P < .001). Conclusion: These findings suggest that miR-214 and PTEN have tumor-suppressor activity and thus, pharmaceutical interventions targeting miR-124 and PTEN may provide a promising therapeutic strategy for the treatment of breast cancer. |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهمن یوسفی | دوازدهم |
| نیلوفر ترغازه | دوم |
| مهدی یوسفی | دهم |
| میلاد بسطامی | هشتم |
| حسین صمدی کفیل | دهم |
| سید مصطفی میر | یازدهم |
| صونا رفیعیان | ششم |
| انصار کریمیان | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1016@j.mgene.2020.100668.pdf | 1398/12/24 | 464839 | دانلود |
