چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Osteosarcoma, as a common malignant neoplasm in children and adolescents, still remains a challenge for conventional therapeutic regimens. In the meantime advent of innovative and revolutionary techniques such as drug delivery systems and smart nano-biomaterials seems promising in tackling these complications. In this study, we designed a smart nano-system consisting of a magnetic inner core and polymeric outer shell with cationic moieties for targeted delivery and enhanced uptake of methotrexate anticancer agent for Saos-2 cell line. The designed nano-formulation was characterized and its drug loading capacity and drug release profile were studied as well that about 60% of methotrexate was released in the first 12 h. The efficacy of the nano-formulation in killing cancer cells was assessed using MTT, cellular uptake, and uptake flow-cytometry. Our in-vitro results confirmed the prepared nano-system has a potential for delivery of anticancer drugs against the Saos-2 cell line and suggests more investigations such as in-vivo tests to be implemented. |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهمن یوسفی | هفدهم |
| محمد رحمتی | دهم |
| فروغ عالمی سرج | نهم |
| مهدی یوسفی | سیزدهم |
| فرهاد جدیدی نیارق | دوازدهم |
| دلشاد احمدی | اول |
| علیرضا صادقپور تیمور لوئی | هفتم |
| نفیسه خلقتی | چهاردهم |
| سید مصطفی میر | ششم |
| مجتبی زارعی | دوم |
| انصار کریمیان | هشتم |
| رویا صالحی قره ورن | یازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| pagination_JDDST_101584 (1).pdf | 1398/12/24 | 1738040 | دانلود |
