چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Modeling of drug solubility and its experimental determination using automated techniques have great impor- tance in the pharmaceutical industry. Mesalazine solubility was measured in a non-aqueous system of propylene glycol and ethanol at various temperatures using an updated laser-based monitoring combined with gravimetric measurement. The obtained solubility data were fitted to diverse cosolvency models including the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models, and the mean relative deviations of the predicted solubility data by the mentioned models were calculated. Furthermore, the apparent thermodynamic properties of mesalazine dissolution process were computed by using the van't Hoff and Gibbs equations. The combined usage of the automated solubility monitor- ing together with thermodynamic modeling is deemed as highly promising for the pharmaceutical industry and particular results of mesalazine add to a database of drug solubility. |
| نویسنده | نفر چندم مقاله |
|---|---|
| وحید جویبان قراملکی | اول |
| ابوالقاسم جویبان | دوم |
| سالار همتی | چهارم |
| الهه رحیم پور | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| A laser monitoring technique for determination of mesalazine solubility.pdf | 1398/12/16 | 394444 | دانلود |
