چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The authors synthesized core-shell smart nanoparticles composed of poly (N-isopropylacrylamide)-b-poly (L-lactide) (PNIPAAm–b-PLA) and developed for narcotic antagonists’ drug-delivery purpose. Micelle structure was verified by 1H-NMR, FT-IR, and TEM. Effect of drug loading, polymer composition, and temperature on micelles morphology and diameter was investigated. Stimuli-responsive behaviors of these nanoparticles were determined using a three-factor full factorial experiment. Naltrexone was successfully incorporated into the PLA cores. By varying the PLA to PNIPAAm ratio, drug loading content, and release time were changed. Results suggest that smart micelles can be suitable for preparation of sustained release systems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | اول |
| سودابه داوران | پنجم |
| امیر احمد خندقی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 7-Int.J.Polym.Mater,2013,Naltrexon.pdf | 1398/12/16 | 964488 | دانلود |
