Synthesis, Characterization, and Viscoelastic Behavior of Thermothickening Poly (N-Isopropylacrylamide- Methacrylicacide-Vinylpyrrolidone) Nanogels as an Injectable Biocompatible Drug Carrier
Synthesis, Characterization, and Viscoelastic Behavior of Thermothickening Poly (N-Isopropylacrylamide- Methacrylicacide-Vinylpyrrolidone) Nanogels as an Injectable Biocompatible Drug Carrier
نویسندگان: رویا صالحی قره ورن , سودابه داوران
کلمات کلیدی: Anticancer, biocompatible nanogels, complexation, dual thermo-=pH-responsive, injectable drug delivery, oscillatory
rheological measurement
نشریه: 15324 , 1 , 64 , 2014
| نویسنده ثبت کننده مقاله |
رویا صالحی قره ورن |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات کاربردی دارویی |
| کد مقاله |
71381 |
| عنوان فارسی مقاله |
Synthesis, Characterization, and Viscoelastic Behavior of Thermothickening Poly (N-Isopropylacrylamide- Methacrylicacide-Vinylpyrrolidone) Nanogels as an Injectable Biocompatible Drug Carrier |
| عنوان لاتین مقاله |
Synthesis, Characterization, and Viscoelastic Behavior of Thermothickening Poly (N-Isopropylacrylamide- Methacrylicacide-Vinylpyrrolidone) Nanogels as an Injectable Biocompatible Drug Carrier |
| ناشر |
4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| In the present work, the preparation of dual thermo-=pH-responsive nanogels composed poly (NIPAAm-MAA-VP) was investigated as an injectable carrier in which doxorubicin hydrochloride (DOX) was opted as an anticancer agent. The SEM
photomicrographs showed that copolymer was almost spherical in shape with the mean diameter below 30 nm. Using dynamic oscillatory the gel-like behavior was observed at 37C for the crosslinked polymer. Biocompatibility of the synthesized nanoparticles and superior antitumor activity of DOX-loaded nanoparticles were proved by in vitro cytotoxicity assay. The system is expected to be valuable for the delivery of chemotherapeutic agents in the treatment of solid tumors. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 15-Yazdi, Int.J.Polym.Mater,2014.pdf | 1398/12/16 | 2932915 | دانلود |
