چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The objective of this study was to synthesize and characterize two novel four-arm star-shaped copolymers of Nisopropylacrylamide (NIPAAm), methacrylic acid (MAA), N,N-(dimethylamino) ethyl methacrylate (DMAEMA) and 1- vinyl-2-pyrrolidone (VP) that was initiated from a new tetramethacrylate monomer (TMAM) as the core by the free radical polymerization approach. Novel multiacrylic monomer was synthesized via three key consecutive reactions. All the intermediates and the final product have been fully characterized. The polymerization reaction was conducted by the core first method and the star-shaped copolymers were analyzed by FT-IR, 1H NMR and Thermo-Gravimetric Analysis (TGA). MTT assay was used to evaluate in vitro cytotoxicity of the star copolymers on lung cancer cell lines. These star copolymers showed no in vitro cytotoxicity to A549 cells. The results showed that these copolymers can be promising drug carriers because they showed no in vitro cytotoxicity and they have various functional groups for association and interaction with drugs. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا صالحی قره ورن | سوم |
| سالار همتی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10-Fibers and Polymers 2014,Heydarpoor.pdf | 1398/12/16 | 543569 | دانلود |
