Interaction, Controlled Release, and Antitumor Activity of Doxorubicin Hydrochloride From pH-Sensitive P(NIPAAm-MAA-VP) Nanofibrous Scaffolds Prepared by Green Electrospinning
Interaction, Controlled Release, and Antitumor Activity of Doxorubicin Hydrochloride From pH-Sensitive P(NIPAAm-MAA-VP) Nanofibrous Scaffolds Prepared by Green Electrospinning
نویسندگان: رویا صالحی قره ورن , مرتضی اسکندانی , سودابه داوران
کلمات کلیدی: Anticancer, Box-Behnken design, cytotoxicity, green electrospinning, ionic interaction, nanofibers, sustained release
نشریه: 15324 , 1 , 63 , 2013
| نویسنده ثبت کننده مقاله |
رویا صالحی قره ورن |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات کاربردی دارویی |
| کد مقاله |
71375 |
| عنوان فارسی مقاله |
Interaction, Controlled Release, and Antitumor Activity of Doxorubicin Hydrochloride From pH-Sensitive P(NIPAAm-MAA-VP) Nanofibrous Scaffolds Prepared by Green Electrospinning |
| عنوان لاتین مقاله |
Interaction, Controlled Release, and Antitumor Activity of Doxorubicin Hydrochloride From pH-Sensitive P(NIPAAm-MAA-VP) Nanofibrous Scaffolds Prepared by Green Electrospinning |
| ناشر |
6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Biocompatible and pH-sensitive poly (N-isopropylacrylamide-co-methacrylic acide-co-vinylpyrrolidone) [P(NIPAAm-MAA-VP)] nanofibers were prepared as a delivery vehicle for sustained release of doxorubicin hydrochloride (DOX) as an anticancer drug. The structure and morphology of nanofibers were investigated by SEM, FTIR, and XRD. P(NIPAAm-MAA-VP)–DOX complex was formed at pH 7 because of ionic interactions between DOX and polymers. P (NIPAAm-MAA-VP) nanofibers tailored to desire diameters with bead free morphology by optimizing the electrospinning parameters DOX release from P (NIPAAm-MAA-VP) DOX complex was investigated as a biological on–off switch for the design of an intelligent drug delivery system triggered by external pH changes. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 9-Int.J.Polym.Mater,2014,fiber.pdf | 1398/12/16 | 5471970 | دانلود |
