چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Early diagnosis of diseases is based on emerging predictive molecules which is important for clinicians to estimating the risk of the disease progression to prescribe personalized therapies. Survivin is coded by BIRC5 gene and plays a key role in inhibition of apoptosis, also is involved in cell homeostasis and pathogenesis of autoimmune diseases. The role of survivin in pathogenesis of Behcet’s Disease (BD) is not well understood. The aim of this study was to assess BIRC5 mRNA methylation pattern in peripheral blood mononuclear cells (PBMC) in patients with BD and its association with disease activity. In this study, DNA methylation in promoter of survivin were assessed between 43 BD patients and 44 healthy controls using MSP assay. Over a period of 1 year (2017 to 2018), blood samples were collected from the patients referring to Rheumatology Clinics. Promoter methylation level of survivin was evaluated by MSP (methylation-specific PCR) technique. The difference between the disease activity and methylation of BIRC5 gene amongst the patients and healthy controls was none significant. There was no association between survivin level and clinical characteristics including arthritis, skin and CNS involvements. Therefore, BIRC5 gene methylation may not serve as a useful biomarker for diagnosis and/or monitoring disease activity in BD. |
| نویسنده | نفر چندم مقاله |
|---|---|
| یاسمین پهلوان | اول |
| علیرضا خبازی اسکویی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ArchRheumatol-2021-36-185.pdf | 1401/12/02 | 215206 | دانلود |
