چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The alleged effects of serotonergic agents in alleviating levodopa-induced dyskinesias (LIDs) in parkinsonian patients are debatable. To this end, we systematically reviewed the serotonergic agents used for the treatment of LIDs in a 6-hydroxydopamine model of Parkinson’s disease in rats. We searched MEDLINE via PubMed, Em-base, Google Scholar, and Proquest for entries no later than March 2018, and restricted the search to publica-tions on serotonergic agents used for the treatment of LIDs in hemiparkinsonian rats. The initial search yielded 447 citations, of which 49 articles and one conference paper met our inclusion criteria. The results revealed ten different categories of serotonergic agents, including but not limited to 5-HT1A/BR agonists, 5-HT2AR antagonists, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitor (SNRIs), and tricyclic antidepressants (TCAs), all of which improved LIDs without imposing considerable adverse effects. Although there is promising evidence regarding the role of these agents in relieving LIDs in hemiparkinsonian rats, further studies are needed for the enlightenment of hidden aspect of these molecules in terms of mecha-nisms and outcomes. Given this, improving the quality of the pre-clinical studies and designing appropriate clini-cal trials will help fill the bench-to-bedside gap. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید صدیق اعتقاد | دوم |
| فرشته فرج دخت | اول |
| علیرضا مجدی | سوم |
| فریبا پاشازاده | چهارم |
| سید مهدی وطن دوست | پنجم |
| مجتبی ضیائی | ششم |
| پوران کریمی | هشتم |
| جواد محمودی | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Mahmoudi_02032020_proof.pdf | 1398/12/14 | 383785 | دانلود |
