چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background:Chloroquine (CQ) is generally prescribed as the front-line antimalarial drug of choice to treat Plasmodium vivaxinfections; however, some clinical CQ-resistant P. vivaxisolates have been indigenously reported around the world during the last decade. Methods:In this study,P. vivaxisolates (n=52) were obtained from autochthonous samples in southeast Iran during 2015–2017. The genomic DNA of samples was extracted, amplified (nested PCR) and sequenced by targeting the multidrug-resistance 1 gene. To verify the global genetic diversity of CQ-resistantP. vivaxstrains, the sequences ofPvmdr1originating from Asia and the Americas were retrieved. Results:A total of 46 haplotypes were grouped into three distinct geographical haplogroups. The haplotype diversity and occurrence rates ofPvmdr1976F/1076Lmutations indicate that the efficacy of CQ is being compromised in Mexico, China, Nicaragua, Thailand, Brazil (2016), Ethiopia, Mauritania (2012) and southwest India in the near future. The cladistic phylogenetic tree showed that Pvmdr1sequences isolated from the southeast Asian clade has a partial sister relationship with the American clade. Conclusions:The current findings will serve as a basis to develop appropriate malaria control strategies and public health policies in symptomatic imported malaria cases or plausible CQ-resistantP. vivaxstrains |
| نویسنده | نفر چندم مقاله |
|---|---|
| عادل اسپوتین | اول |
| محمود محامی اسکوئی | دوم |
| احسان احمدپور | سوم |
| مهدی پارسائی | چهارم |
| مصطفی فرمانی | هشتم |
| صبا قلی پور اوصالو | هفتم |
| شیما امامی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Spotin et al, 2020.pdf | 1399/02/15 | 697739 | دانلود |
