| ogs serve as the most important definitive hosts forToxocara canis—a causative agent
of human toxocariasis and one of the most widespread zoonotic helminth worldwide.
The present study was undertaken to assess the global prevalence ofT. canisinfection
in dogs. PubMed, Scopus, Web of Science, EMBASE and SciELO were searched to
identify relevant studies. A random-effects model was used to estimate the overall
and the subgroup-pooled prevalences across studies, and heterogeneity was assessed
via theI
2
test. The data were categorized according to WHO-region, different types of
dogs, risk factors and environmental variables. From a total of 4370 peer-reviewed
publications, 229 articles that studied 13,010,004 dogs in 60 countries met the final
inclusion criteria. The overall prevalence of Toxocara infection in dogs was 11.1%
(95% CI, 10.6–11.7%). The estimated prevalence in the different WHO-regions ranged
from 6.4% to 19.2%: Eastern Mediterranean (19.2%, 13.7–25.5%), Africa (18.5%,
13.7–23.9%), South-East Asia (11.9%, 6.8–18.2%), North America (11.1%, 10.6–11.7%),
South America (10.9%, 7.6–14.6%), Europe (10.8%, 8.9–12.9%) and Western Pacific
(6.4%, 3.3–10.2%). Young (<1 year of age), stray, rural and male dogs had a significantly
(P<0.001) higher prevalence of infection than older, pet, urban or female dogs. The
prevalence was higher in low income countries and regions at a low geographical
latitude, close to the equator, characterized as having tropical climates. From this review,
it is estimated that100 million dogs are infected withToxocaraaround the world. This
highlights the need for an increased focus on implementing affordable, appropriate
control programs to reduce the public health threat of toxocariasis as a zoonosis of
global importance. |