چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| علی احمدعلی پور | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Prenatal morphine exposure causes a variety of neuro-behavioral alterations observed in later life. In this study we investigated the effects of exercise and enriched environment on alterations in water maze performance and hippocampal BDNF levels induced by prenatal morphine in rats. On gestation days 11–18, pregnant rats were injected twice daily with morphine or saline. Offspring were subjected to postnatal exercise and enriched environment for 30 days and afterwards, spatial memory and BDNF level were investigated. Prenatal morphine exposure changed water maze performance in a paradoxical manner that is inconsistent in two phases; weakening on acquisition phase and improving on retention phase. Postnatal exercise and enriched environment increased performance in both phases of water maze in prenatally saline exposed rats. In prenatally morphine exposed, postnatal exercise and enriched environment rats had paradoxical effects that is improving in acquisition phase in male and female offspring but inconsistent (different) in retention phase in different groups and aspects of probe retention test. Prenatal morphine exposure also caused reduction in hippocampal BDNF levels in female rats, and postnatal exercise and enriched environment had different effects on male and female groups of morphine and saline groups and increased BDNF levels only in prenatally morphine exposed female offspring. Our results demonstrate that postnatal exercise and enriched environment can improve some of changes in water maze performance and hippocampal BDNF levels caused by prenatal morphine exposure. |
| کلمات کلیدی | Morphine. Prenatal. Exercise. Enriched Environment. Memory |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| cetificate.jpg | 1398/12/04 | 676809 | دانلود |
| abstract.pdf | 1399/11/27 | 144379 | دانلود |
