چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مرضیه فتحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ریز فناوری دارویی |
| کد مقاله | 71080 |
| عنوان فارسی مقاله | Chitosan-g-poly(lactide) micellar nanoparticles as an efficient antioxidant delivery system |
| عنوان لاتین مقاله | Chitosan-g-poly(lactide) micellar nanoparticles as an efficient antioxidant delivery system |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | http://nanomedsafety.com/ |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2020 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/11/05 الی 1398/11/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://nanomedsafety.com/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامیه گشتاسبی | اول |
| مرضیه فتحی | دوم |
| یداله امیدی | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Antioxidants; Astaxanthin; CS-g-PLA; delivery system |
| خلاصه مقاله | Due to the negative impact of reactive species (including free radicals) on humans and animals, the investigations to find effective substances (antioxidants), which protect living organisms against their damaging influence are carried out throughout the world. Astaxanthin (ATX) is an antioxidant that shows efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and low thermolability often limits its antioxidant efficacy in biomedical applications. Here, we developed a formulation of chitosan-g-poly(lactide)(CS-g-PLA ) micellar nanoparticles to protect astaxanthin’s antioxidant activity. Polylactide and chitosan (CS) are biodegradable and biocompatible materials that widely been used as drug delivery vehicles. To prepare CS-g- PLA, the solubility of CS in organic solvents was improved by the complexation of CS with sodium dodecyl sulphate (SDS) simply by mixing acidic solutions of CS and SDS. After purification, graft copolymerization of lactide (LA) on CS backbone was carried out using ring opening polymerization. The obtained solution was purified via precipitation with tris buffer and washing with distilled water respectively and finally it was freeze-dried. The chemical structures of the copolymers were confirmed by Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance (1H NMR) and thermogravimetric analysis (TGA). The efficiency of the developed nanoparticles would be evaluated for the encapsulation of astaxanthin as a potent antioxidant agent. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Congress 4.pdf | 1398/11/16 | 48446 | دانلود |
| certificate 4.jpg | 1398/11/16 | 4340651 | دانلود |
