چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مرضیه فتحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ریز فناوری دارویی |
| کد مقاله | 71079 |
| عنوان فارسی مقاله | Alginate-chitosan microbeads as a promising drug delivery system of astaxanthin for rectal cancer treatment |
| عنوان لاتین مقاله | Alginate-chitosan microbeads as a promising drug delivery system of astaxanthin for rectal cancer treatment |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 3rd Nanomedicine and Nanosafety Conference (NMNS 2020) |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2020 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/11/05 الی 1398/11/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://nanomedsafety.com/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامیه گشتاسبی | اول |
| مرضیه فتحی | دوم |
| یداله امیدی | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Oxidative Stress,Reactive Oxygen Species(ROS), Astaxanthin (ATX), drug delivery , Cancer |
| خلاصه مقاله | is growing support for the concept of reactive oxygen species, which are known to be implicated in the range of diseases, may be important progenitors in carcinogenesis, including colorectal cancer (CRC). CRC is one of the most common cancers worldwide, with the highest incidence rates in western countries. In the last decades, association between oxidative stress and CRC has been intensively studied. Astaxanthin (ATX) is a gold carotenoid showing efficient scavenging ability and is considered as a candidate in new therapies for preventing and treating cellular oxidative stress. That the first defensive cell barrier against oxidative stress and ROS is nuclear factor erythroid 2-related factor 2(Nrf2), a basic leucine zipper (bZIP) transcription factor. It can express cytoprotective genes, such as antioxidant proteins, phase I, II and detoxification proteins. This study was designed to evaluate the protective effects of encapsulated ATX in chitosan-alginate (CSALG) microbeads on HT29 cells against oxidative stress and the possible underlying mechanism. To this end, ATX encapsulated CS-ALG microbeads were prepared by the spraying of CS-ALG/ATX mixture solution into the CaCl2 solution. The structural properties, size distribution, and surface morphology were investigated using FT-IR, XRD and scanning electron microscopy. The biocompatibility of CS-ALG microbeads was examined in vitro via MTT assay. Cytotoxicity study revealed that the prepared microbeads are cytocompatible and indicate no significant toxicity on HT29 cells. The apoptosis rate was measured with DNA ladder method, and flow cytometry. Nrf2 expression was examined with Real-time PCR. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Congress 3.pdf | 1398/11/16 | 43257 | دانلود |
| Certificate-3.jpg | 1398/11/16 | 4442643 | دانلود |
