چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مرضیه فتحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ریز فناوری دارویی |
| کد مقاله | 71078 |
| عنوان فارسی مقاله | Poly (propylene fumarate) based scaffold for cartilage tissue engineering |
| عنوان لاتین مقاله | Poly (propylene fumarate) based scaffold for cartilage tissue engineering |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 3rd Nanomedicine and Nanosafety Conference (NMNS 2020 |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2020 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/11/05 الی 1398/11/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://nanomedsafety.com/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیده نازنین امیریعقوبی تبریز | اول |
| مرضیه فتحی | دوم |
| یداله امیدی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Cartilage is a resilient and smooth elastic tissue, protects the ends of long bones at the joints. Proteoglycans are considered as the main structural components of the cartilage extracellular matrix.1 Cartilage does not contain blood vessels, so it has a very slow turnover of its extracellular matrix and does not repair. Thus, cartilage tissue engineering revitalizes cartilage function and includes scaffold, cell, and regulatory factors as a promising approach by providing biomaterial according to extracellular matrix architecture in order for nutrient delivery and chondrogenic differentiation. Poly(propylene fumarate) (PPF) is a linear unsaturated synthetic polyester, which has been considered as a potential orthopedic scaffold for the regeneration of bone tissue. PPF is degraded through hydrolysis of ester bonds to form fumaric acid and propylene glycol as nontoxic materials. It is synthesized from 1, 2-propylene glycol and diethyl fumarate utilizing zinc chloride as catalyst and hydroquinone as a cross-linking inhibitor. PPF is a biocompatible polymer with a mechanical property, which offers crosslinked networks by carbon-carbon double bond to form 3D printed scaffolds.2 Chitosan (CS) is a deacylated form of chitin and positively charged natural linear polysaccharide plays a profound role in chondrogenic attachment, proliferation, and differentiation.3 In the present study, composite scaffold containing PPF and CS were prepared for cartilage tissue engineering and regeneration. FT-IR, H-NMR, XRD, compression test, and SEM were performed to evaluate the physico/chemical properties of the prepared scaffold. Proliferation and differentiation of human adipose stem cell to chondrocyte were investigated via MTT assay, real-time PCR and toluidine blue staining. |
| کلمات کلیدی | Cartilage tissue engineering, Poly (propylene fumarate), Chitosan, Composite |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| congress 2.pdf | 1398/11/16 | 40106 | دانلود |
| Certificate 2.jpg | 1398/11/16 | 4434175 | دانلود |
