چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مرضیه فتحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ریز فناوری دارویی |
| کد مقاله | 71075 |
| عنوان فارسی مقاله | Poly(caprolactone) based nanofibers for bone tissue engineering |
| عنوان لاتین مقاله | Poly(caprolactone) based nanofibers for bone tissue engineering |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | (3rd Nanomedicine and Nanosafety Conference (NMNS 2020 |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2020 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/11/05 الی 1398/11/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://nanomedsafety.com/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیده نازنین امیریعقوبی تبریز | اول |
| مرضیه فتحی | دوم |
| یداله امیدی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Bone is a kind of dynamic and vascularized tissue that possesses a great regenerative ability. The matrix tissue encompasses various minerals (e.g., calcium, magnesium and phosphorus materials), in which hydroxyapatite plays a key in terms of the mechanical strength of the bone tissue. Bone tissue engineering revitalizes bone function and includes scaffold, cell, and regulatory factors as a promising alternative to autografts and allografts by providing biomaterial according to extracellular matrix architecture in order for nutrient delivery and osteogenic differentiation.1 Poly(caprolactone) (PCL) is an important aliphatic polymer, consisting of hexanoate units. It shows unique features for bone tissue engineering, in large part due to its mechanical property and biodegradability. PCL is synthesized by polycondensation of 6-hydroxyhexanoic acid and ring-opening polymerization (ROP) of ε-caprolactone (e-CL).2 Poly (ester-urethane-urea) (PEUU) was synthesized based on diisocyanates, PCL and chain extender such as 1, 4-butane diamine. The electrospinning method fabricates highly porous and thin fibers large surface areas, ease of functionalization and excellent mechanical property for various applications. The tissue engineering field utilizes the electrospinning method for scaffold preparation.3 In the present study, electrospun scaffolds containing PEUU were prepared for bone tissue engineering and regeneration. FT-IR, H-NMR, compression test, and SEM were performed to evaluate the physico/chemical properties of the prepared scaffold. Proliferation and differentiation of human adipose stem cell to osteoblast were investigated via MTT assay, real-time PCR and alizarin red staining. |
| کلمات کلیدی | bone tissue engineering, poly(caprolactone), electrospinning, stem cells |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Congress 1.pdf | 1398/11/16 | 44243 | دانلود |
| Certificate 1.jpg | 1398/11/16 | 4409922 | دانلود |
