چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Although breast cancer has been identified as one of the main cancer-related deaths among women during some last decades, recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to decrease in mortality rate of breast cancer. However, the scenario of breast cancer is yet going on and further improvements in the current ant-cancer therapeutic approaches are needed. Several factors are present in the tumor microenvironment which help to cancer progression and suppression of anti-tumor responses. Targeting these cancer-promoting factors in the tumor microenvironment has been suggested as potent immunotherapeutic approach for cancer therapy. Among the various tumor-supporting factors, cyclin dependent kinases (CDKs) are proposed as novel promising target for cancer therapy. These factors in association with cyclins play a key role in cell cycle progression. Dysregulation of CDKs which leads to increased cell proliferation has been identified in various cancers, such as breast cancer. Accordingly, development and use of CDK-inhibitors have been associated with encouraging results in treatment of breast cancer. However, it is unknown that inhibition of which CDK is the most effective for breast cancer therapy. Since the selective blockage of CDK1 alone or in combination with other therapeutics has been associated with potent anti-cancer outcome, it is suggested that CDK1 may be considered as the best CDK target for breast cancer therapy. However, several questions are remaining in this issue which should be addressed in the future studies. In this review, we will discuss on the role of CDK1 in the breast cancer progression and treatment. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده ایزدی | اول |
| افشین نیک خو | دوم |
| مهدی یوسفی | هفتم |
| فرهاد جدیدی نیارق | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| CDK1 in Breast Cancer Implications for Theranostic Potential.pdf | 1399/04/25 | 6748473 | دانلود |
