| The solubility of caffeine in non-aqueous mixed solutions of carbitol and ethanol at different temperatures are de-
termined by a shake-flask method and fitted to some reported cosolvency models including the van't Hoff, the
double log-log, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff,
and the modified Wilson models. Along with solubility, the densities of caffeine saturated mixtures are also mea-
sured and correlated with the Jouyban-Acree model. In order to study the accuracy of the employed models, the
mean relative deviations (MRD%) of the back-calculated solubility and density data are calculated. Furthermore,
the apparent thermodynamic properties of caffeine dissolution process in the mixed solutions of carbitol and eth-
anol are also calculated by using van't Hoff and Gibbs equations. |