| Mesalazine solubility is important to study in solvent mixtures for chemical and pharmaceutical engineering. Therefore, solubility of the drugwas determined in water/1-propanol mixtures at T=(293.2 to 313.2) K. To represent the solid-liquid equilibrium for these systems, the van't Hoff, Apelblat, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), modified Wilson, Jouyban-Acree, Jouyban-Acree-van't Hoff, Wilson, NRTL and UNIQUAC models were employed. The thermodynamic quantities of dissolution andmixingwere calculated for mesalazine in aqueous 1-propanol solutions at harmonic temperature. Further, calculations of inverse Kirkwood-Buff integrals showthat this drug is preferentially solvated bywater in all themixtures,with exception of x1 = 0.20, at 298.2 K. |