| Hyaluronic acid (HA) is widely used in the biomedicine due to its
biocompatibility, biodegradability, and nontoxic properties. It
is crucial for cell signaling role during morphogenesis, inflammation,
and wound repair. After hydrogel formation, HA easily
is converted to elastic sheets in order to use in preclinical and
clinical applications. In addition, HA-derived hydrogels are easily
used as vectors for cell and medication in tissue repairing and
regenerative medicine. Moreover, in comparison with other
polymers, HA -based hydrogels play a key role in in cellular behavior,
including stem cell differentiation. The current paper
reviews both basic concepts and recent advances in the development
of HA-based hydrogels for biomedical applications. |