چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | علیرضا شفیعی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | روانپزشکی و علوم رفتاری |
| کد مقاله | 70812 |
| عنوان فارسی مقاله | تغییرات مولکولی ژن اینترلوکین 6 در بیماران مبتلا به اسکیزوفرنیا در مقایسه با گروه کنترل : نتایج حاصل از کوهورت ارس |
| عنوان لاتین مقاله | Molecular changes of IL-6 gene in patients with schizophrenia compared to healthy control: results from ARAS cohort |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 8th basic and clinical neuroscience congress |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/09/27 الی 1398/09/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://bcnc.ir/News.aspx?NID=23 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Associate prof. of Psychiatry , Research Center of Psychiatry and Behavioral science , Faculty of Medicine , Tabriz University of Medical Science , Tabriz ,Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا شفیعی | دوم |
| مرتضی اسدی | اول |
| سارا فرهنگ | سوم |
| ریچارد بروگمن | چهارم |
| داریوش شانه بندی | پنجم |
| میلاد اسدی | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Etiology of Schizophrenia is multifactorial. Numerous investigators suggest a probable role for immune system in the pathogenesis. The aim of this study was to compare the gene expression of interleukin-6 (IL-6) in patients with first episode schizophrenia and healthy controls. Method: this study was a part of Azeri recent onset/acute phase psychosis survey (ARAS). 40 patients with recent onset schizophrenia and 40 healthy controls were recruited. After a structures psychiatric interview, groups were matched in terms of gender and age. From the peripheral blood, T-cells were first isolated and then total RNA was extracted. After cDNA synthesis using different primers, expression rate of the interleukin-6 gene was calculated. Result: The mean age of the patients was 29.7 years, all had Azeri Turkish ethnicity, 67.5% were male. IL-6 gene expression was significantly increased in patients with schizophrenia compared to controls (p = 0.032) Conclusion: This is the first report from patients with Azeri ethnicity. This study adds evidence for a possible correlation between schizophrenia and immune response that could be either autoimmune or viral reactivation mechanism. Cytokines are suggested as potential biomarkers for disease activity. |
| کلمات کلیدی | psychosis, immune system, interleukins |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| BCNC2019_AbstractBook_2.pdf | 1398/10/28 | 3836172 | دانلود |
