| The solubility profile of caffeine in the binary non-aqueous mixtures of N-methyl-2-pyrrolidone (NMP) and eth-
anol at different temperatures is determined and the obtained data are fitted to some linear and non-linear
cosolvency models including the van't Hoff, the double log-log, the mixture response surface, Yalkowsky,
Jouyban-Acree, Jouyban-Acree-van't Hoff, and the modified Wilson models. The measured density data of caf-
feine saturated solutions as another physico-chemical property are also correlated with the Jouyban-Acree
model and the results are discussed. In order to investigate the accuracy of the applied models, the mean relative
deviations (MRD%) of the back-calculated solubility data is calculated. Furthermore, the apparent thermody-
namic properties of caffeine dissolution process are also calculated by using van't Hoff and Gibbs equations. |