چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
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| اسماعیل قره پاپاق | اول |
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| خلاصه مقاله | APPLICATION OF PET/CT IN BONE TUMORS Esmaeil Gharepapagh,M.D1 1Nuclear Medicine division,Radiology Dept,Tabriz University of Medical Sciences *esmaeil.gharepapagh@gmail.com 1. Clinical Nuclear Medicine * ⃞ BACKGOROUND: Malignant tumors are associated with increased glycolysis compared to normal tissues,likely related to increased number of GLUT transporters and a higher concentration of hexokinase within malignant cells.As a glucose analog, 18F-FDG is transported into cells by surface GLUT-1 transporters and then incorporated into the cell where it is phosphorylated and trapped.18F-FDG PET/CT has high sensitivity and specificity in discriminating between sarcomas and benign tumors. OBJECTIVE:More than 90% of bone tumors : Osteosarcoma (the most common) Chodrosarcoma Ewing sarcoma Chondroma Malignant fibrous histiocytoma 18F-NaF has been available for many years but has recently been rediscovered as the application of PET has grown. This radiotracer has a similar distribution to the single-photon-emitting 99mTc-MDP used in general nuclear bone scan imaging but has the advantage of improved image resolution and faster image acquisition time afforded by PET. In the spectrum of primary bone tumors, one of the main indications for PET/CT with 18FNaF is in the assessment of osteosarcoma. Usually, 18FNaF has higher specificity compared to FDG in localizing sclerotic bone lesions, but has inferior performance in the assessment of lytic bone lesions. For this reason, the combined use of NaF and FDG has been studied with initial success. METHODS: In hybrid PET-CT imaging ,CT is used for two different purposes: 1- Attenuation Correction: Providing initial intensities of photon before attenuation by soft tissues with CT-derived attenuation coefficient maps. 2- Anatomical Localization : (after being assured no misregistration takes place) . SUV is a semi-quantitative parameter to measure amount of uptake in a region SUV is defined as:[mCi/ml(decay corrected) in tissue] /mCi injected/body weight in grams RESULTS: In dual phase PET/CT,malignant lesions continually increase their uptake of radiotracer,while benign conditions usually are characterized by increased uptake on the early-phase, but decreased or monotonic uptake on delayed-phase image.Most of malignant lesions have higher levels of SUV compared to the benign lesions. CONCLUSION: PET/CT is a hybrid imaging technique increasingly used in the diagnosis, staging, and follow-up of primary bone neoplasms.The use of PET/CT in some malignancies such as lymphoma and multiple myeloma has been steadily established. PET/CT can add valuable information in distinguishing benign from malignant lesions and in the staging of malignant bone tumors. PET/CT can play a role in biopsy planning, treatment planning, and response assessment. KEYWORDS: PET/CT,bone tumors,SUV REFERENCES: 1- The role of PET/CT in the assessment of primary bone tumors 2- FDG PET/CT of primary bone tumors |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| poster template.pptx | 1398/10/23 | 561080 | دانلود |
| APPLICATION OF PET (3).docx | 1398/10/23 | 18137 | دانلود |
| Scan.jpg | 1398/10/23 | 263661 | دانلود |
