| The previous reports have established a strong link between diet, lifestyle, and gut microbiota population with the onset of the
colorectal cancer (CRC). Administration of probiotics has become a particular interest in prevention and treatment of CRC.
As potential dietary complements, probiotics might be able to lower the risk of CRC and manage the safety of traditional
cancer therapies such as surgery, radiation therapy, and chemotherapy. This review investigates the promising effects of probiotics
as biotherapeutics, with due attention to possible clinical application of yeast probiotics in prevention and treatment
of CRC. In addition, various underlying anti-cancer mechanisms are covered here based on scientific evidence and findings
from numerous experimental studies. Application of probiotics as biotherapeutics in CRC, however, needs to be approved
by human clinical trials. It is of prime concern, to find potential probiotic strains, effective doses for administrations and
regimes, and molecular mechanisms involved in prevention and treatment. |