چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| اشرف فخاری | اول |
| اسماعیل قره پاپاق | دوم |
| شهرام دبیری اسکوئی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | BACKGROUND: Graphene Quantum Dots (GQDs) as nanoparticles derived from graphene have been considered as big interest in realm of pharmacy, bioimaging and biosensors due to their incredible properties. Because of owing expanded physical capacity (both side of each GQDs layer) and wide range of functional groups, they bind to wide range of molecules and atoms. In this study we introduced a new aspect of GQDs, through providing gamma emitting radio-complex as 99mTc-(N-GQDs) in order to facilitate radiolabeling of agents lacking potential to chelate of radioisotope. OBJECTIVE: In this study we made an attempt to show a new potential of Graphene Quantum Dots (GQDs) nano particles as a multipurpose substrate for developing 99mTc-labeled scintigraphy agents through promoting of either radioisotope chelation and water solubility of ligands simultaneously. METHODS: N-GQDs were synthesized and radiolabeled with technetium-99m to obtain 99mTc-(N-GQDs). The 99mTc-(N-GQDs) was injected to healthy Wistar rats for biodistribution studies. Dosimetry studies were done to find out effective radiation dose of each organs. RESULTS: The characterization of N-GQDs were showed that the high purity of N-GQDs particles in the size range of 5-10 nm were obtained. ITLC surveys demonstrated that 99mTc-(N-GQDs) were prepared in high radiochemical purity (RCP≥95%). Filtration of 99mTc-(N-GQDs) with 0.1 µm filter was proved that 77.38 % of particles are less than 0.1µm. The biodistribution studies showed that the 99mTc-(N-GQDs) were eliminated by kidneys. Aggregation of 99mTc-(N-GQDs) in spleen was considerable because of particles size. The ovaries and uterus showed more concentration of 99mTc-(N-GQDs) within 2h after injection compared with other organs. Dosimetry studies introduced kidneys as critical organ. CONCLUSION: Our study demonstrated Technetium-99m labeling of N-GQDs is feasible and radiolabeling of poor water soluble ligands as well as molecules without effective functional groups can potentially be labeled by Technetium-99m using this system. |
| کلمات کلیدی | Radiolabeling, Graphene Quantum Dots, Technetium-99m, biodistribution |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| press.jpg | 1398/10/21 | 359228 | دانلود |
| davari.jpg | 1398/10/21 | 381850 | دانلود |
| Fakhari.Abstract.pdf | 1398/10/21 | 418038 | دانلود |
