چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Cinnamon essential oil is known to have antioxidant and antibacterial properties, whichmay accelerate, wound healing. This study was conducted to evaluate the effects of anointment prepared fromCinnamon verumessential oil (Cverum) in infected woundmodel. An experimentally excisional infected wound model was induced in mice. Circularexcisional wound model of 5 mm surface area was surgically created and inoculated with107CFU of each of two bacterial strains ofStaphylococcus aureusandPseudomonasaeruginosa. The animals were divided into three groups and topically treated with softyellow paraffin (control) and ointments containing 2% and 4%Cverum. The mRNA levelsof insulin-like growth factor I (IGF-1), fibroblast growth factor-2 (FGF-2) and vascularendothelial growth factor (VEGF), epidermal keratin, fibroblasts, fibrocytes, immunecells, and vascular distribution as well as epithelialization ratio were investigated in orderto evaluate the effects ofCverumon wound healing. Tissue total antioxidant capacityand malondialdehyde levels (MDA) were also evaluated. Topical administration ofCverumremarkably shortened the inflammatory phase, increased fibroblast distribution,collagen deposition, and accelerated the cellular proliferation, reepithelialization and ker-atin synthesis. The mRNA levels of IGF-1, FGF-2 and VEGF were remarkably higher inCverum-treated groups (especially 2%) in comparison control group. Topical administra-tion ofCverumincreased antioxidant power and reduced MDA content in comparisonto control animals.C verumaccelerates wound healing by upregulating the IGF-1, FGF-2,and VEGF expression and increasing cell proliferation, collagen synthesis, andreepithelialization ratio. |
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| حامد همیشه کار | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| 2019-Farahpour-The Kaohsiung Journal of Medical Sciences.pdf | 1398/10/11 | 3293239 | دانلود |
