چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | صدف کلهری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 70602 |
| عنوان فارسی مقاله | بررسی اثرات محافظتی دفریپرون در کاهش عوارض قلبی دوکسوروبیسین در مدل رت |
| عنوان لاتین مقاله | Assessment of Cardio protective Effect of Deferiprone on Doxorubicin-Induced Cardiac Toxicity in a Rat Model |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 21st International Conference on Cancer and Clinical Oncology 21st International Conference on Cancer and Clinical Oncology |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Turkey |
| شهر محل برگزاری کنگره/ همایش | istanbul |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/09/28 الی 1398/09/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://panel.waset.org/conference/2019/12/istanbul/ICCCO |
| آدرس علمی (Affiliation) نویسنده متقاضی | دانشگاه علوم پزشکی تبریز-مرکز تحقیقات کاربردی دارویی |
| نویسنده | نفر چندم مقاله |
|---|---|
| صبا غفاری | سوم |
| صدف کلهری | اول |
| حسین بابائی | دوم |
| یدالله آذرمی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract Introduction: Doxorubicin (DOX)-induced cardiotoxicity is widely-known as the most severe complications of anthracycline based chemotherapy in patients with cancer. It is unknown whether Deferiprone(DFP), could reduce the severity of DOX-induced cardiotoxicity by inhibiting free radical reactions. Thus, this study was performed to assess the protective effect of Deferiprone on DOX-induced cardiotoxicity in a rat model. Methods: The rats were divided into five groups. Group one was control group. Group 2 was DOX (2 mg/kg/day, every other day for 12 days), and Group three to five which receiving DOX as in group 2 and DFP 75,100 and 150 mg/kg/day, for 19 days, respectively. DFP was starting 5 days prior to first DOX injection and two days after the last DOX injection throughout the study. Electrocardiographic and hemodynamic studies, along with histopathological examination were conducted. In addition, serum sample was taken and total cholesterol,Malone dialdehyde,triglyceride,albumin,AST,ALT,total protein,lactate dehydrogenase,total anti-oxidant and creatine kinase were assessed. Result: Our results showed normal structure of endocard, myocard and pericard in control group. Pathologic data such as edema, hyperemia, bleeding, endocarditis, myocarditis and pericarditis, hyaline degeneration, cardiomyocyte necrosis, myofilament degeneration and nuclear chromatin changes were assessed in all groups. In DOX group, all pathologic data was seen with mean grade of 2±1.25. In DFP group with a dose of 75 and 100 mg the mean grade were 1.41± 0.31 and 1±.23, respectively. In DFP group with a dose of 150, the pathologic data showed a milderchanges in compare with other groups with e mean grade of 0.45 ±0.19. Most pathologic data in DFP groups showed significant changes in compare with DOX group (p<0.001). Discussion: The results also showed that DFP treatment significantly improved DOX-induced heart damage, structural changes in the myocardium and ventricular function. Our data confirm that DFP is protective against cardiovascular-related disorders induced by DOX. Clinical studies are needed to be involved to examine these findings in human. |
| کلمات کلیدی | Keywords: Doxorubicine, deferiprone, cardiomyopathy, Rat |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| invitation.pdf | 1398/10/08 | 132703 | دانلود |
| Abstract.docx | 1398/10/08 | 16213 | دانلود |
| certificates.pdf | 1398/10/08 | 417790 | دانلود |
| best-presentation-award[2028].pdf | 1398/10/08 | 388032 | دانلود |
| ticket_1012494641.pdf | 1398/10/08 | 307746 | دانلود |
| ticket.png | 1398/10/08 | 68495 | دانلود |
| 1.jpg | 1398/10/09 | 526033 | دانلود |
| 2.jpg | 1398/10/09 | 399869 | دانلود |
| Assessment_of_Cardioprotective_Effect_of_Deferiprone_on_Doxo.pdf | 1398/10/23 | 136293 | دانلود |
