| Chamomile, as a rich source of phenolic compounds and terpenoids, seems to be an effctive approach in the
management of chronic conditions such as diabetes mellitus. The aim of this systematic review was to evaluate
evidence from animal and human studies of the effcts of chamomile on metabolic risk markers and complications of diabetes mellitus. The literature search was conducted in PubMed, SCOPUS, Embase, ProQuest and
Google Scholar electronic and were considered the articles published on April 2019. Original studies that investigated the effct of chamomile in diabetes mellitus which met the inclusion criteria were eligible. After
screening 208 citations, 15 studies were included. The results of these studies demonstrated a signifiant effct of
chamomile administration on metabolic profies. All 12 studies that examined the impact of chamomile supplementation on glycemic control indicated this feature. Four of the fie studies appraising the impact of chamomile on lipid profies showed that it improved dyslipidemia. Six studies showed that chamomile markedly
decreased oxidative stress particularly malondialdehyde. Altogether, four chamomile studies evaluating diabetes
complications, including renal and hepatic profies, found signifiant decreases compared to controls. These
fidings extend the novel functions of chamomile in the improvement of glycemic and lipid profies and oxidative stress indicators in diabetes mellitus and related complications. In-depth studies focusing on underlying
mechanisms are warranted to make useful conclusions. |