چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| جلال عبدالعلیزاده | دوم |
| سید امیر شکوری - بیوتکنولوژیست | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | |
| خلاصه مقاله | The human gut microbiota has an important result on many aspects of human physiology like as metabolism, nutrient absorption, and immune system. Inconsistency of the microbiota has been occupied in several sicknesses including inflammatory, obesity, asthma, psychiatric illnesses, and specially cancers. First and foremost, probiotics have been illustrating to show a protective role against cancer development in animal models. Clinical application of probiotics specified that some probiotic strains could reduce the rate of postoperative inflammation in cancer patients. Despite momentous developments in treatment modalities, millions of cancer-related deaths continue to occur annually, often as a value of developing resistance against the range of available chemotherapeutic drugs. Furthermore, accessible anti-cancer chemotherapeutic agents display limited efficacy, often have severe side effects, and are so costly. Also, the finding pharmacological agents that do not have these drawbacks is compulsory. The aim of this study was to investigate the effect of Bifidobacterium bifidum on HT-29 cancer cells by evaluation of Rad54L, P53 pathway. For evaluation of cytotoxicity of Bifidobacterium bifidum on colorectal cancer cell line (HT-29) MTT assay was done. In addition, to evaluating RAD54L and P53 genes expression Real- Time PCR had done. RAD54L is one of the most important protein that involved in DNA repair. Results of MTT assay demonstrated that Bifidobacterium bifidum playing potential role in reducing the viability of HT-29. Expression of RAD54L and P53 from Real Time PCR illustrate that B. bifidum could increase apoptosis and reduced cell division. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The Potential.pdf | 1398/10/03 | 436621 | دانلود |
| Potential Role Poster.pdf | 1398/10/21 | 368112 | دانلود |
