چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In the present study, the solubility of ketoconazole is measured by a shake – flask method in the binary solvent mixtures of 2-propanol + water at different temperatures. The experimental solubility data are correlated/back- calculated by some cosolvency models i.e. van't Hoff, Yalkowsky, Jouyban-Acree, Jouyban-Acree-van't Hoff, the mixture response surface and the modified Wilson models. Moreover, the density of ketoconazole saturated so- lutions is fitted by Jouyban-Acree model and the obtained equation is reported. The accuracy of these models is investigated by calculation of the corresponding MRD%. The apparent thermodynamic parameters including dis- solution standard enthalpy change (ΔH ∘ ), standard entropy change (ΔS ∘ ), Gibbs free energy change (ΔG ∘ ) for ke- toconazole dissolution are calculated by using van't Hoff and Gibbs equations. Moreover, the preferential solvation analysis demonstrates that ketoconazole is preferentially solvated by water in water-rich and in 2- propanol-rich mixtures, but preferentially solvated by 2-propanol in mixtures of composition 0.19 b x 1 b 0.58. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیرا زادعلی اصغر | اول |
| محمد برزگر جلالی | چهارم |
| الهه رحیم پور | پنجم |
| ابوالقاسم جویبان | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Solubility of ketoconazole in the binary mixtures of 2-propanol and water.pdf | 1398/09/27 | 555484 | دانلود |
