| Introduction: Pelvic organ prolapse (POP) is a common disease which present as symptomatic descent
of the anterior or posterior vaginal wall prolapse, uterus or apical prolapse subsequent to hysterectomy,
and entrocele. Since, social and cultural factors have impact on interval between symptoms
incidence and seek for medical care, diagnosis method and treatment process, it was important to
prepare a guideline for management of the Iranian women with POP. Methods and Materials: This
guideline has drawn on the evidence based search strategy developed for study goals to provide a
native guideline. Therefore, during a systematic search, all clinical guidelines relevant to the subject
extracted. Of 85 study, 35 study with evidences grades, systematic reviews or high quality clinical
trials selected and further grading performed. Current recommendations presented with due attention
to best data available in the literature or based on a mixture of clinical experience and experts’ panels
decisions. Summary of Recommendations: Pelvic floor muscle training recommended as the firs
line treatment in patients with urinary incontinence or POP (GradeA). Physicians should recommend
pessaries to all women seeking treatment for their prolapse (Grade A). Subtotal hysterectomy is not
recommended to prevent further prolapse (Grade A). in term of recurrence, dyspareunia and stress
urine incontinency (SUI), abdominal sacropexy is better than vaginal sacropexy, however, these
results cannot be extended to reoperation rate and patients’ satisfaction (Grade: A). Since graft using
fascia increases rate of recurrence, it should not be used ruing abdominal sacrocolpopexy (Grade:
A). Round ligament suspension does not provide any effect on uterus or vaginal prolapse treatment
(Grade: B). in patients who underwent first time anterior colporaphy, local tissue should be repaired
instead of mesh usage (Grade: B). Anatomic outcomes of the polypropylene mesh are much better
than anterior colporahy, however, enough data is not provided on its functional outcomes (GradeA).
Levator ani muscle fixation should be prevented in sexually active women (Grade C). In women
who suffer concurrent POP and SUI, both should be repaired in the same time (Grade A). |