| خلاصه مقاله | Backgrounds: Orthotropic heart transplantation (HTX) remains as gold standard for these End stage patients. Pulmonary hypertension (PH) occurs in up to 70% of patients with advanced heart failure which classified as 'passive' or 'reactive'.We reviewed the relationship between preoperative pulmonary hemodynamic and early post-transplant mortality. Material and method: In a retrospective study Between 2007 through May 2018, a total of 125 heart transplant, 72 adult patients with heart failure underwent Orthotropic HTX procedures at Rajaie Cardiovascular Medical and Research Center. All adult patients were enrolled in this trial. Pulmonary hemodynamic Indices werepulmonary vascular resistance (PVR), trans-pulmonary gradient (TPG), Diastolic pulmonary gradient (DPG) and pulmonary artery compliance (PAC). End points were 30-day and one year survival. Student'st test for paired parameters and Fisher's exact test for relationship of hemodynamic parameters and outcome after transplantation were used. Result: Sixty four study patients (16 female, 48 male) were age ranged from 14 to 60 years (mean 28.249.7).There was no statistically significant correlation between PVR, PVRI, TPG, DPG, PAC and 30-day post-transplant mortality. Thirty-day survival was similar between low TPG or DPG and high TPG or DPG groups. But the 1 year mortality rate after transplantation was significantly higher in patients with higher PVR, TPG and DPG. Conclusion: Pre-operative pulmonary hemodynamic parameters such as PVR, TPG and DPG can predict year, but not 30 days post-transplant mortality. DPG Cannot predict 1-year post-transplant mortality belter than TPG. |