چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Acute myeloid leukemia (AML) as a progressive genetic disorder is characterized by the accumulated mutations in hematopoietic progenitor cells. Mutations in Wilms' Tumor 1 (WT1) gene have been detected in AML patients. This tumor suppressor gene activates the long non-coding RNA maternally expressed 3 (MEG3). MEG3 is a tumor suppressor lncRNA which is down-regulated in many human cancers. The importance of the WT1-MEG3 axis in suppressing tumor growth potentiates this axis as a novel approach for effective treatment of AML. In this study, we investigated the association between polymorphisms in MEG3 (rs11160608, rs7158663, rs3087918) and WTI (rs16754) and risk of AML in Iranian population. A total of 100 AML cases and 100 healthy controls from the North West of Iran were enrolled in our work. The polymorphisms rs7158663 and rs3087918 were genotyped by PCR-restriction fragment length polymorphism (RFLP) method. The amplification-refractory mutation system (ARMS)-PCR method was used for identification of MEG3 rs11160608 and WT1 rs16754 polymorphisms. The rs7158663 and rs3087918 were shown to increase the risk of AML. In summary, our findings indicate a possible role for MEG3 in the pathogenesis of AML. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم رضازاده | یازدهم |
| جلال قره سوران | دوم |
| محسن مرادی | ششم |
| عظیم رضامند | نهم |
| شمسی عبدی | اول |
| امیر عطااله هیرادفر | هشتم |
| حسن حسین زاده | پنجم |
| فرشته نصیری گنجینه کتاب | چهارم |
| محمد طاهری | دهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 91070452.pdf | 1398/10/30 | 379649 | دانلود |
| 1-s2.0-S2214540019300957-main.pdf | 1398/09/17 | 756350 | دانلود |
