چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Quantitative analyses of antiepileptic drugs are required in clinic and to rational dosage adjustment, the clinician needs the blood levels of these drugs. A highperformance liquid chromatography with spectrophotometric detection has been developed and validated for simultaneous determination of some antiepileptic drugs in plasma of patients with epilepsy. Methods: A simple procedure based on deproteinization by acetonitrile was used for pretreatment of plasma samples. Liquid chromatographic analysis was carried out on a Nova- Pak® C18 analytical column, using a ternary mixture of potassium dihydrogen phosphate buffer (pH 6.0)-acetonitrile-2-propanol (63:22:15, v/v/v) as the mobile phase, at a flow rate of 1.0 mL min-1. Results: Calibration curves were linear over a range of 1–40 μg mL-1 for phenobarbital, 1– 30 μg mL-1 for phenytoin, 0.3–15 μg mL-1 for carbamazepine and 0.5–6 μg mL-1 for carbamazepine epoxide. Conclusion: The simple sample pre-treatment, combined with the fast chromatographic run was used for the determination of antiepileptic drugs for a large number of patient samples. |
| نویسنده | نفر چندم مقاله |
|---|---|
| اعظم صمدی | اول |
| محمد برزگر | سوم |
| شهرام صادق وند | چهارم |
| شادی شیوا | پنجم |
| ابوالقاسم جویبان | ششم |
| مریم خوب نسب جعفری | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Pharmaceutical Sciences, 209, 25(4), 345-351.pdf | 1398/09/17 | 488125 | دانلود |
