| خلاصه مقاله | One of the major applications of tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous
wounds [1]. In this respect, many important clinical milestones have been reached in the past decades. However, currently available
skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor
integration with host tissue [2,3]. Engineering skin substitutes by tissue engineering approach has relied upon the creation of threedimensional scaffolds as extracellular matrix (ECM) analog to guide cell adhesion, growth, and differentiation to form skinfunctional and structural tissue [4,5]. In the last years, the use of collagen nanofibers (NFs) as one of the biodegradable biomaterials
in nature for tissue engineering and related fields, such as wound healing, has been more developed. For this purpose, we
fabricated the reinforced NFs (Zein/ polycaprolactone (PCL) /Collagen) incorporated with zinc oxide nanoparticles and Aloe-vera
(NFs/ZnO/Alv) by using the electrospinning technique |