| Nucleic acid vaccines (NAVs) have recently been tested for cancer therapy. DNA and mRNA vaccines deliver genetic information coding for tumor antigens (TAs) to the host who then produces immune responses against cancer cells that express the TAs. NAVs are easy, safe, and simple to manufacture, however, so far they have not been considered viable alternatives to peptide vaccines. Choosing the right TAs, insufficient immunogenicity, and immunosuppressive nature of cancer are some challenges in this way. Common and different improving efficiency approaches for cancer NAVs are covered here. |