چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The aim of this work was to study the solubilization behavior and thermodynamics of ketoconazole solubility inthe binarymixtures of propylene glycol (PG) and wateratfive different temperatures rangingT=293.2–313.2 K.Some cosolvency mathematical models including van't Hoff equation, Yalkowsky model, Jouyban-Acree model,Jouyban-Acree-van'tHoffmodel, modifiedJouyban-Acree-van'tHoffmodel, the modifiedWilson model, thedou-ble log-log model and the mixture response surface model werefitted to the experimental results, and the meanrelative deviations (MRD%) of the back-calculated solubilities were calculated. Density of the solutions saturatedwith ketoconazole over the entire solvent composition and temperature range was also determined and the ob-tained density values were correlated/back-calculated with the Jouyban–Acree model, resulting in a very accu-rate calculation of the densities withMRD% of 0.1%. Moreover, apparent thermodynamic properties ofketoconazole dissolution process in the investigated mixed solvents including entropy, enthalpy and Gibbs freeenergy were computed using van't Hoff and Gibbs equations. Furthermore, preferential solvation analysis dem-onstrates that ketoconazole is preferentially solvated by water in water-rich mixtures but preferentially solvatedby PG in the other mixtures. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیرا زادعلی اصغر | اول |
| الهه رحیم پور | دوم |
| محمد برزگر جلالی | پنجم |
| ابوالقاسم جویبان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 6.pdf | 1398/09/14 | 608630 | دانلود |
