| We read with interest the Review by Widmann and Heneka on the long-term consequences of sepsis.1
Sepsis and its associated complications are thought to be the foremost causes of morbidity and mortality in patients in intensive-care units (ICU) worldwide. Sepsis, a potentially fatal sequel to infection, results from a cascade of pro-inflammatory compounds released in response to infection. Consequently, multiple-organ systems might be affected, leading to their failure.
Sepsis-associated encephalopathy, a life-threatening yet reversible deterioration of mental status that occasionally accompanies sepsis, is the most common type of encephalopathy encountered in patients in the intensive care unit; sepsis-associated encephalopathy contributes to increased mortality in these patients, and those who survive often have long-term, disabling, cognitive dysfunction or other devastating outcomes, including impaired memory, attention, mental-processing speed, and visual-spatial abilities. This long-term disabling state can affect all aspects of a patient's life, including the ability to return to normal daily activity or work, imposing a further burden to their families and healthcare providers.2 |