چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| تیمور حضرتیان | پنجم |
| محمد رحمتی | سوم |
| مجید مبصری | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Diabetes mellitus is a group of metabolic disorders. One of the most common types of diabetes is diabetes type 2 in which insulin secretion; glucose utilization is decreased due to insulin resistance and glucose production increased. Preparation of pH-sensitive nanohydrogels with human insulin and evaluate insulin amount and delivery rate in different pH conditions are the aims of this study. Methods and Materials: The pH-sensitive nanohydrogels are synthesized and surface morphology was evaluated by scanning electron microscopy (SEM) and nanohydrogels diameter was measured by transmission electron microscopy (TEM) the amount of loaded insulin in nanohydrogels was assessment by FTIR. Then the effect of different pH on the amount and rate of release of insulin from nanohydrogels were studied in vitro conditions. Finally, the amount of insulin released in different conditions was measured with the HPLC method. Findings: Our study shows that synthesized nanohydrogels in 1, 4 Dioxan solvent without cross-linker have the most loading amount and its banded insulin releases minimal in the acidic environment of the stomach and has greatest releases and absorption in the basic environment like intestinal conditions . discussion: Insulin is protected in the stomach pH condition and passes through the gastric acid barrier and in the intestine has been released. |
| کلمات کلیدی | Nanohydrogels, Diabetes Mellitus, Insulin |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract preparation.pdf | 1398/09/10 | 179550 | دانلود |
| Certificate preparation.jpg | 1398/09/10 | 355589 | دانلود |
