Budesonide solubility in polyethylene glycol 400 + water at different temperatures: Experimental measurement and mathematical modellig
Budesonide solubility in polyethylene glycol 400 + water at different temperatures: Experimental measurement and mathematical modellig
نویسندگان: الهه رحیم پور , اسماعیل محمدیان , ابوالقاسم جویبان
کلمات کلیدی: Solubility
Budesonide
PEG 400
Binary solvent mixture
Cosolvency models
نشریه: 18106 , 2019 , 274 , 2019
| نویسنده ثبت کننده مقاله |
ابوالقاسم جویبان |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات آنالیز دارویی |
| کد مقاله |
70130 |
| عنوان فارسی مقاله |
Budesonide solubility in polyethylene glycol 400 + water at different temperatures: Experimental measurement and mathematical modellig |
| عنوان لاتین مقاله |
Budesonide solubility in polyethylene glycol 400 + water at different temperatures: Experimental measurement and mathematical modellig |
| ناشر |
4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| The goal of this work was to study the solubilization and thermodynamic behavior of budesonide (BDS) in the
aqueous mixtures of polyethylene glycol 400 (PEG 400) within the temperature range of 293.2–313.2 K by
using a shake-flask method. The obtained molar solubility data were correlated by using some cosolvency
models. The mean relative deviations (MRDs%) for back-calculated solubility data were employed to show the accuracy of the fitness. Furthermore, the apparent thermodynamic properties of dissolution of BDS in the binary
mixtures of solvent including entropy, enthalpy and Gibbs free energy were computed using van't Hoff and
Gibbs equations. Finally, by means of IKBI method was observed that BDS was preferentially solvated by PEG
400 in all the mixtures compositions. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 1-s2.0-S0167732218347937-main.pdf | 1398/09/10 | 513645 | دانلود |