| We read with great interest the paper of Chen and Sung
reporting two cases of gingival and localized alveolar bone
necrosis following root canal treatment with arsenic
trioxide-containing paste.1 However, in the first sentence
of the introduction section in their report, Haly Abbas
(930e994 AD) was introduced as the first to use arsenic
trioxide in dental treatment in 1492.1 First, to the best of
our knowledge, early records of arsenical use in dental
treatment date back to before biblical times.2 Later,
Rhazes (865e925 AD) used arsenicals (Zarnikh) in dental
and gingival treatments decades before Haly Abbas.
Throughout medieval Persia, yellow and red arsenics
(arsenic sulfides) were commonly used in dental extraction,
devitalizing pulps of teeth, dental caries, toothache,
gingivitis, spongy gum, and bleeding gingiva.2,3 Second,
Haly Abbas, wrote his medical encyclopedia called Kitab
al-Maliki (The Royal Book) (Fig. 1) in 965. Written in Arabic,
The Royal Book was translated into Latin in 1127, and was
printed under the name “Liber Regalis” in 1492. In other
words, the use of arsenicals in dental treatment was indicated
by Haly Abbas in 965 AD, rather than 1492.4 Third, in
his Liber Regalis, Haly Abbas recommended using arsenic
(arsenic sulfides) rather than white arsenic (arsenic
trioxide) for devitalizing the pulps of teeth.2 To the best of
our knowledge, white arsenic or arsenic trioxide was not
used as a therapeutic agent in medieval Persian medicine;
white arsenic was known for its lethality in the medieval
era |