| Since the dawn of medicine, the human heart and the cardiovascular
systemwere of wide spread interest to scientists. Despite this long-lasting
history, the true concept of the blood circulation within the body
remained unknown for many centuries [1]. Although there were some
early references to the possible existence of a connection between the
arteries and the veins in medieval medicine, the dominant belief of those
days was that blood moved in a unidirectional path in both arteries and
the veins towards the peripheral tissues and consumed by them [2–5].
At present, William Harvey (1578–1657), an English physician, is
known as the first figure in medical history who precisely described the
human vasculature and the circulation of the blood within a closed
vascular system. The details on the peripheral to central direction of
venous blood flow were an important part of Harvey's theory [5].
Interestingly, our recent study affirms that Abd al-Latif al-Baghdadi
(1162–1231 AD), a writer and physician in the era of the Islamic Medicine
Golden Age (9th–12th centuries AD), provided an early and correct
description for the direction of the venous blood flow long before the
efforts made by Harvey [1,6,7].
Muwaffaq al-Din Muhammad 'Abd al-Latif ibn Yusuf al-Baghdadi, best
known as Abd al-Latif al-Baghdadi, an Arab writer, historian, physician,
philosopher, Egyptologist, and traveler, was born in Baghdad (the current
capital city of Iraq) (Fig. 1). Al-Baghdadi authored a number of medical
books related to the various fields of medicine [6].
Al-Tibb min al-Kitabwa-al-Sunna (Medicine from the Book and the Life of
the Prophet) was one of Al-Baghdadi's writings devoted to the healing
arts. In this work, al-Baghdadi stated his opposition to the theory of
unidirectional central to peripheral venous blood flow. He believed that
the venous blood returns back fromthe body organs, reaches finally to the
kidneys where some amount of it is excreted from the body through the
urine. To justify his theory, al-Baghdadi provided an example. His line of
reason and argument was that the change in urine color was a feasible
likelihood due to the topical use of henna on the skin (a natural coloring
agent traditionally used for cosmetic purposes). In his opinion, this
coloring agent was absorbed by the tissues to which it was topically
applied, and was absorbed into the venous blood stream, and moved
backward (peripheral to central); and finally, by the passage of venous
blood from the kidneys, henna was excreted into the urine [7].
A review of the modern literature will show several reports on the
possibility of severe hemolysis following the topical use of Henna in cases
with glucose-6-phosphate dehydrogenase deficiency, an event that can
eventually cause urine discoloration [8]. This argument can support the
above-mentioned medieval theory on the color changes in the urine due
to the topical use of Henna. |