| COPD: Chronic Obstructive Pulmonary Disease;
ETCO2: End Tidal CO2; ETT: Endo Tracheal Tube; PaCO2: Arterial
Pressure of CO2; AHA: American Heart Association; ROSC: Return of
Spontaneous Circulation; CPR: Cardiopulmonary Resuscitation
“Laudation to the God of majesty and glory! Obedience to him
is a cause of approach and gratitude in increase of benefits. Every
inhalation of the breath prolongs life and every expiration of it
gladdens our nature; wherefore every breath confers two benefits
and for every breath gratitude is due.”1
Saadi Shirazi, the prominent Persian-Iranian poet living in the 12th-
13th century whose aphorism “Bani Adam” or the Children of Adam
ornaments the entrance of the United Nations, in the introduction
section of the Golestan, has elaborately described the importance of the
two sections of respiration.
Capnography is one of the non-invasive methods used for the
measurement of End-tidal CO2 values (ETCO2). Values for ETCO2
alter based on the CO2 concentrations in each respiratory cycle [1].
Ancient Greeks believed that human body is equipped with a kind
of “combustion engine” producing smoke, i.e. breathing; hence, the
termcapnography is derived from the Greek word “Capnos” meaning
smoke [1,2].
The mechanism of respiration includes two stages of oxygenation
and ventilation with are considered as the natural physiological
functions of the body that should be taken into consideration in the
evaluation of the intubated patients and non-intubated patients with
normal respiration. Oxygenation can normally be monitored using
pulse oxymetry whereas capnography can provide more accurate
information on each respiration cycle regarding ventilation, perfusion,
cardiac output, pulmonary blood flow and metabolic status [1].
Carbon dioxide is produced a human body following glucose
metabolism which is later delivered to pulmonary blood circulation
transferred to the exhaled air through the alveoli. In expiration phase,
primarily the air in the upper airways is exhaled; the process is followed
by the expiration of the air content of the lower airways. Capnogram
demonstrates CO2 content of the expired air throughout the whole
expiration phase. Most technologies used in the capnography are
based on infrared wave; as CO2 absorbs infrared waves in the specific
wavelength of 4.26 nm. Therefore, the amount of the absorbed waves is
in close relation with the CO2 content of the expired air [1-3].
In patients with normal pulmonary function, apart from their age,
the difference between ETCO2 and arterial carbon dioxide pressure
(PaCO2) is a constant figure (2-5 mmHg) [2,3]. This difference
originates from the dead alveolar spaces in a normal lung which is
ineffective in the ventilation process. Capnography device demonstrates
ETCO2 Values and its related curves [2]. A normal capnogram has been
illustrated in figure 1 in which the blue line is indicative of PaCO2. The
distance between the blue line and section III (C-D distance) is the
normal befriends between ETCO2 and PaCO2.
In this figure, A is the start point of inspiration; D is the end point
of expiration from which the new inspiration cycle starts. The height of
the curve is related to ETCO2 whereas its width is related to expiration
time [1,3]. The changes in the shape of the curve could be suggestive
of the underlying diseases and the alterations in the ETCO2 values
could be utilized for the assessment of the severity of the diseases and
response to treatment [1]. An emergency medicine physician should be
aware of abnormal curves caused by technical problems of the device
and also the contributing physiological and pathological conditions in
order to monitor the patients more accurately and to increase his or her
diagnostic abilities |