چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Liver, as a vital organ, is responsible for a wide range of biological functions to maintain homeostasis and any type of damages to hepatic tissue contributes to disease progression and death. Viral infection, trauma, carcinoma, alcohol misuse and inborn errors of metabolism are common causes of liver diseases are a severe known reason for leading to end-stage liver disease or liver failure. In either way, liver transplantation is the only treatment option which is, however, hampered by the increasing scarcity of organ donor. Over the past years, considerable eforts have been directed toward liver regeneration aiming at developing new approaches and methodologies to enhance the transplantation process. These approaches include producing decellularized scafolds from the liver organ, 3D bio-printing system, and nano-based 3D scafolds to simulate the native liver microenvironment. The application of small molecules and micro-RNAs and genetic manipulation in favor of hepatic diferentiation of distinct stem cells could also be exploited. All of these strategies will help to facilitate the application of stem cells in human medicine. This article reviews the most recent strategies to generate a high amount of mature hepatocyte-like cells and updates current knowledge on liver regenerative medicine. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید وحید حسینی | اول |
| نازیلا فتحی معروفی | دوم |
| سپیده سقطی | سوم |
| ناهیده اسدی | چهارم |
| مسعود دارابی امین | پنجم |
| سعید نظری سلطان احمد | ششم |
| رضا رهبرقاضی | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tranlational.pdf | 1398/09/03 | 1464464 | دانلود |
| 123.pdf | 1398/09/03 | 46252 | دانلود |
