Epigenetic insights in the diagnosis, prognosis and treatment selection in CRC, review and update

مجریان: صفر فرج نیا

خلاصه روش اجرا: The gradual accumulation of genetic and epigenetic alterations can lead to the development of colorectal cancer. In the last decade, a lot of research has been done to discover how methylation as an epigenetic alteration leads to carcinogenesis. While Methylation is a biological process, it can influence gene expression by affecting the promoter activity. Promoter methylation is associated with up or downregulation of genes involved in critical pathways, including cell cycle, DNA repair, and cell adherence. Hence, the promoter methylation can be used as a molecular tool for early diagnosis, improving treatment, and predicting treatment resistance. This article reviews the role of methylation in critical pathways in critical pathways in CRC. Also, existing information on methylation detection methods and therapeutic sensitivity or resistance due to DNA methylation were reviewed. Current knowledge on potential methylation biomarkers for diagnosis and prognoses of CRC has also been discussed. Our survey proposes that multi-biomarker panel is more efficient than a single biomarker in the early diagnosis of colorectal cancer