چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS‐CSCs play a key role in the resistance to treatment and relapse and metastasis through self‐ renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell‐phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سما ایزدپناه | اول |
| پرستو شعبانی شیشوان | دوم |
| علی عاقبتی ملکی | سوم |
| امیر باغبانزاده | چهارم |
| لیلی عاقبتی | هفتم |
| بهزاد برادران | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| cancer stem cell.pdf | 1398/09/02 | 1289486 | دانلود |
| Untitled.png | 1398/11/27 | 84794 | دانلود |
